Bharat Biotech's indigenous COVID-19 vaccine 'COVAXIN' gets approval for phase I & II human clinical trials
Tuesday, 30 June 2020 () The SARS-CoV-2 strain was isolated in NIV, Pune and transferred to Bharat Biotech. The indigenous inactivated vaccine was developed and manufactured in Bharat Biotech's BSL-3 (Bio-Safety Level 3) High Containment facility located in Genome Valley, Hyderabad.
India's Covaxin has entered clinical trials while the Drug controller Genral of India gave the nod for another vaccine by Zydus Cadila for phase I and II human trials. ICMR has asked Bharat Biotech to fast-track vaccine trials keeping a roll-out date of August 15th in mind. With 2 vaccines in the...
In the ending ceremony of Jagannath Rath Yatra attendees were seen flouting social distancing norms amid increasing number of coronavirus infection cases. The annual, 13 days Jagannath Rath Yatra has ended with 'rasagulla' offers to goddess lakshmi by lord Jagannath on July 04. After denying it earlier, the Supreme Court has given permission to organise the annual Rath Yatra on June 22. As instructed, the procession has to be organised in a limited way without public attendance and only the servitors who have tested negative for COVID-19 can participate in the festival. Jagannath Rath Yatra is one of the auspicious festivals in India.
President Donald Trump said during July 4th celebrations in Washington D.C. Saturday that the U.S. has made a "lot of progress" in its fight against the pandemic even as two large states posted record increases in COVID-19 cases.
There has been a surge in domestic child abuse during the coronavirus pandemic, suggests the experience of one specialist UK children's hospital.The study was published in the journal Archives of Disease in Childhood. In just one month, the number of new cases rose by 1493% compared with the same period in the previous three years, pointing to a "silent pandemic" in 2020, suggest the authors.They compared the numbers of new cases of head injury caused by physical abuse among very young children seen between 23 March and 23 April this year and the same period in 2017, 2018, and 2019. March 23 marked the start of lockdown and a period of national self-isolation in the UK in a bid to curb the spread of SARS-CoV-2, the virus that causes COVID-19 infection.Ten children (six boys and four girls) with suspected abusive head trauma presented for treatment during March-April. Their ages ranged from 17 days to 13 months old. This figure compares with an average of 0.67 cases a month for the same period in 2017, 2018, and 2019, representing an increase of 1493% in 2020, say the authors. The symptoms prompting a hospital visit included colic (persistent crying for no obvious reason) in 5 of the infants; breathing issues (apnoea) and loss of consciousness in 4; seizures in 2; extensive bruising in 5; swollen scalp in 5; and marks caused by repeated picking at the skin (excoriation) in 1 child.The infants were comprehensively assessed. This included head, spine, and skeletal scans, as well as detailed eye and whole body checks. The results revealed blood pooling in the brain (subdural haemorrhage) in 6 infants; brain swelling in 4; bruising of the brain tissue (parenchymal contusion) in 4; skull fractures in 4; a bleed on the brain (subarachnoid haemorrhage) in 3; and bone fractures elsewhere in 3 of the infants.The infants' families all lived in areas of significant social and economic deprivation. And there's a complex interplay between abuse, mental health, substance misuse and socioeconomic factors, the authors point out.Two of the parents had a history of criminal activity; 3 had mental health issues; and 4 had financial worries, factors likely to heighten the risk of abusive behaviour, say the authors.
: A recent analysis led by a team of researchers found crucial genomic features that are unique to SARS-CoV -2, the virus that causes COVID-19, and two other deadly coronaviruses, SARS-CoV and MERS-CoV. Published in PNAS, the research reports that these features correlate with the high fatality rate of these coronaviruses as well as their ability to switch hosts from animals to humans. They identified features that could represent crucial elements of coronavirus virulence and allow for detecting animal coronaviruses that have the potential to make the jump to humans in the future. Using an integrated approach that included machine-learning and comparative genomics, authors Ayal B. Gussow, Noam Auslander, Guilhem Faure, Yuri I. Wolf, Feng Zhang, and Eugene V. Koonin identified three previously undetected likely determinants of pathogenicity and zoonotic transmission. These features include enhancement of the nuclear localization signals (NLS) in the nucleocapsid protein and distinct inserts in the spike glycoprotein that appears to be associated with a high case fatality rate of these coronaviruses as well as the host switch from animals to humans. The identified features could be crucial contributors to coronavirus pathogenicity and possible targets for diagnostics, prognostication, and interventions. The enhancement of the NLS in the three coronaviruses that can cause severe diseases (hereafter high-CFR coronaviruses) ) nucleocapsids implies an important role of the subcellular localization of the nucleocapsid protein in coronavirus pathogenicity. Strikingly, insertions in the spike protein appear to have been acquired independently by the SARS and MERS clades of the high-CFR coronaviruses, in both the domain involved in virus-cell fusion and the domain mediating receptor recognition. The gradual enhancement of the NLS in the nucleocapsids and the different insertions in the spike protein of the high-CFR coronaviruses imply that these changes do not reflect a single event that occurred in the common ancestor, but rather a convergent trend in the evolution of the high-CFR viruses. These insertions, most likely, enhance the pathogenicity of the high-CFR viruses and contribute to their ability to zoonotically transmit to humans. The predictions made through this analysis unveil potential critical features in the mechanism of SARS-CoV (/topic/sars-cov)-2 virulence and its evolutionary history, are amenable to straightforward experimental validation and could serve as predictors of strains pathogenic to humans
A start-up company at Hyderabad invented contactless, facial-recognition based thermal screening of employees. This step was taken to avoid spread of coronavirus infection. Sushanth, CEO of Arvi Healthcare while speaking to ANI said, "In times of COVID-19, Arvi thermal kiosks provide a smart, safe and seamless thermal screening experience at workplace. Our made in India solution provides contactless, facial-recognition based thermal screening experience to walk-ins integrated with visitor management, employees access control and attendance solutions. All kiosks are integrated with Aarogya Setu app to provide a safe screening experience."
Hyderabad City Police intercepted one auto trolley in Siddiamber Bazar under Shahinayathgunj Police Station limits and seized smuggled cigarettes worth about Rs. 1.03 crore. Five persons were arrested for illegal import of cigarettes.
A COVID-19 infected patient succumbed at a government hospital in Hyderabad on June 30. In a self-made video, he alleged that there was no one in the hospital and that he was all by himself. Family alleged that he succumbed due to hospital's negligence.
India's Covaxin has entered clinical trials while the Drug controller Genral of India gave the nod for another vaccine by Zydus Cadila for phase I and II human trials. ICMR has asked Bharat Biotech to..
PM Modi is in Leh weeks after clashes in Galwan Valley, CDS Bipin Rawat and Army Chief MM Naravane accompany him; Over 20,000 Coronavirus cases in 24 hours for the first time in India; ICMR to launch..