Madhya Pradesh Home Minister Narottam Mishra has apologised for his ‘I don’t wear mask’ remark. Mishra said that his statement was against the government’s guidelines and also against what Prime Minister Narendra Modi has been advocating. Mishra also urged people to follow all Covid-19 guidelines. It is mandatory to wear a face cover in public places, according to the government's guidelines on the coronavirus. ‘My statement on not wearing a mask appears to be a violation of law. It wasn't in line with the sentiment of the Prime Minister. I accept my mistake and express regret. I'll wear a mask. I also appeal to everyone to wear masks and observe social distancing.’ In Indore, people are even penalized Rupees 200 for not wearing masks. The Congress had also attacked the state Home Minister on his remark. Madhya Pradesh has registered over 1.13 lakh Covid cases so far and the death toll stands at 2,077. Indore is one of the state's worst-affected districts and has registered over 20,000 cases so far with 516 fatalities. Watch the full video for more details.
Credit: HT Digital Content Duration: 01:47Published
India's COVID-19 tally crossed 56-lakh mark on September 23 with a spike of 83,347 new infections. Total COVID-19 cases in the country stand at 56,46,011. Currently, there are 9,68,377 active cases. With 1,085 deaths in last 24 hours, the death toll rises to 90,020. Indian Council of Medical Research reported that 6,62,79,462 samples were tested up to September 22. Further, the Health Ministry informed that India's COVID-19 testing capacity surges to over 12 lakh daily tests.
India's COVID tally crossed 55-lakh mark on September 22 after the country reported a spike of 75,083 new COVID-19 cases. Total COVID case tally stands at 55, 62,664, including 9,75,861 active cases, 44,97,868 discharged. With 1,053 deaths in the last 24 hours, death toll due to COVID reached 88,935. Indian Council of Medical Research reported that 6,53,25,779 samples were tested up to September 21 for the virus. Of these, 9,33,185 samples were tested on September 21.
New research from Cornell University developed potential roadmaps for how the coronavirus infects organs and identifies what molecular factors could help facilitate or restrict infection. "The data suggest that it's not just a respiratory disease," said lead author Cedric Feschotte, a molecular biology professor. "It's much broader than that and has the potential to affect many other organs. Our analyses suggest that there is a wide range of cellular vulnerabilities." The study maps the expression of 28 human genes dubbed 'SCARFs' - SARS-Cov-2 and Coronavirus-Associated Receptors and Factors. By looking at the single-cell RNA expression of these genes, they can predict which tissues and cell types are most vulnerable to coronavirus infection - in both adults and embryos. The team analyzed the RNA expression of healthy human tissues to develop a comprehensive profile of the molecular factors that both facilitate and restrict SARS-CoV2 infection. Without the immune system's ability to respond quickly, Feschotte said, naturally occurring restriction factors already present in the tissues represent the body's main line of defense against SARS-CoV-2. Mapping the different entry points for the virus also is essential for trying to predict where the virus will go after it enters the body. Moreover, by pinpointing the molecular routes of infection, other researchers can use those areas as targets for developing drugs to overcome the infection. The study indicates alternate entry paths for how the virus could enter the lungs, central nervous system, and heart. Their research also supports emerging clinical data that shows SARS-CoV-2 also infect the intestines, kidney, and placenta. They noted that specific groups of cells within the prostate and testes are likely to be permissive for SARS-CoV-2 and may help explain male-specific vulnerabilities. As part of this project, the team also developed an open-access, user-friendly web interface where anyone can look up the single-cell RNA expressions of SCARFs. This will facilitate easy access to data that will help scientists around the world.
A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.
Dogs trained for jsut a week can sniff out the Sars-Cov-2 virus, according to new research. They can differentiate between samples from Sars-Cov-2 infectaded patiens and non-infected people. Dogs could be used in public areas like airports, sport events, borders or other mass gatherings. The research team was led by the University of Veterinary Medicine Hannove (TIHO) in cooperation with the German Army, Hannover Medical School & the University Medical-Center Hamburg-Eppendorf.
Credit: Cover Video STUDIO Duration: 01:01Published
Prime Minister Narendra Modi chaired a high-level virtual meeting with Chief Ministers and Health Ministers of seven COVID-19 high burden (States/UT Maharashtra, Andhra Pradesh, Karnataka, Uttar Pradesh, Tamil Nadu, Delhi and Punjab) to review response and management. While addressing in the meeting, PM Modi said, "There are more than 700 districts in the country but only 60 districts in 7 states are a cause of worry." "I suggest CMs to hold virtual conference with people at district/block level for 7 days. We have to learn from the best practices from across the states," PM Modi added.