The Inca Empire, called Tawantinsuyu by its subjects, was the largest empire in pre-Columbian America. The administrative, political, and military center of the empire was in the city of Cusco. The Inca civilization rose from the Peruvian highlands sometime in the early 13th century. The Spanish began the conquest of the Inca Empire in 1532 and by 1572, the last Inca state was fully conquered.