Beetlejuice Beetlejuice is an upcoming American fantasy horror comedy film directed by Tim Burton from a screenplay by Alfred Gough and Miles Millar, based on a story by Gough, Millar, and Seth Grahame-Smith. A sequel to Beetlejuice (1988), it stars Michael Keaton, Winona Ryder, and Catherine O'Hara reprising their roles from the first film, alongside new cast members Jenna Ortega, Justin Theroux, Monica Bellucci, Arthur Conti, and Willem Dafoe.