Early Onset Dementia And Glymphatic Failure As a Common Final Pathway (Pt.2)

Early Onset Dementia And Glymphatic Failure As a Common Final Pathway (Pt.2)

The potential for early-onset dementia, characterized by cognitive decline before the age of 65, is alarmingly intertwined with the dysfunction of the glymphatic system, an essential neural waste clearance pathway.

This system, reliant on the water channel protein Aquaporin-4, is instrumental in purging the brain of deleterious metabolic byproducts, including amyloid-beta peptides and tau proteins, whose accumulation is a hallmark of neurodegenerative diseases.

However, the emerging understanding of this system's vulnerabilities opens a Pandora's box of bio-warfare possibilities, particularly through agents that exploit amyloidogenic properties to compromise neurologic health.